The intraction effect of ten week combined exercise training (resistance-aerobic) and mix supplemantation (L-carnitine-caffein-arginine) on adiponectin, leptin and lipid profile in obese men

Introduction and purpose: the effect of resistance and aerobic exercise on improving the metabolic conditions of obese people has been confirmed; But the question of whether consuming energy supplements along with exercise improves the metabolic status and blood lipid profile of individuals is a new approach that has been considered. The aim of this investigation was to study the interactive effect of ten weeks of simultaneous training (resistance-aerobic) and mix supplementation (L-carnitine-caffeine-arginine) on lipid profile and leptin and adiponectin levels in obese men. Materials and Methods: in this quasi-experimental and applied study with pretest-posttest design performed on non-athletic obese men, 28 subjects (age: 37.02±3.89yr, height: 174.7±6.57cm and BMI: 34.4±1.24kg/m2) were selected and randomly divided into three groups: 1): resistance-aerobic training and mix supplementation [RAS] (n: 10), 2): resistance-aerobic training and placebo [RAP] (n: 9) and 3): supplementation/detraining [HUS] (n: 9). The mix supplement contained 200mg of caffeine, 1000mg of L-carnitine, and 1000mg of L-arginine taken 40min daily before exercise. Resistance and aerobic trainings were included 30min and 40-45min respectively with moderate intensity for ten weeks and 3d/w. Results: the findings showed that mix supplementation (L-carnitine-caffeine-arginine) with moderate intensity resistance- aerobic training had a significant effect on decrease of plasma leptin (p=0.0001) and increase of adiponectin (p=0.001) levels. Also, the interaction of resistance- aerobic training and mix supplementation in decreased TC, TG and LDL-C levels and increased HDL-C (p<0.05) in non-athlete obese men. Discussion and Conclusion: it can be concluded those ten weeks of mix supplementation (L-carnitine-caffeine-arginine) and moderate intensity resistance-aerobic exercises had a positive effect on metabolic markers and blood lipid profile in non-athletic obese men.